Multipotent neurogenic fate of mesenchymal stem cell is determined by Cdk4-mediated hypophosphorylation of Smad-STAT3

Cyclin-dependent kinase (Cdk) in complex with a corresponding cyclin plays a pivotal role in neurogenic differentiation. In particular, Cdk4 activity acts as a signaling switch to direct human mesenchymal stem cells (MSCs) to neural transdifferentiation. However, the molecular evidence of how Cdk4 a...

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Publicado no:Cell Cycle
Main Authors: Kim, Dong-Young, Lee, Janet, Kang, Dongrim, Lee, Do-Hyeong, Kim, Yoon-Ja, Hwang, Sang-Gu, Kim, Dong-Ik, Lee, Chang-Woo, Lee, Kyung-Hoon
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis 2016
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Reports
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4957601/
https://ncbi.nlm.nih.gov/pubmed/27192561
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15384101.2016.1188230
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