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Noncovalent Intermediate of Thymidylate Synthase: Fact or Fiction?
Thymidylate synthase is an attractive target for antibiotic and anticancer drugs due to its essential role in the de novo biosynthesis of the DNA nucleotide thymine. The enzymatic reaction is initiated by a nucleophilic activation of the substrate via formation of a covalent bond to an active site c...
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| Vydáno v: | J Am Chem Soc |
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| Hlavní autoři: | , |
| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
2016
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4957585/ https://ncbi.nlm.nih.gov/pubmed/27327197 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.6b03826 |
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