S100A1 Protein Does Not Compete with Calmodulin for Ryanodine Receptor Binding but Structurally Alters the Ryanodine Receptor·Calmodulin Complex

S100A1 has been suggested as a therapeutic agent to enhance myocyte Ca(2+) cycling in heart failure, but its molecular mode of action is poorly understood. Using FRET, we tested the hypothesis that S100A1 directly competes with calmodulin (CaM) for binding to intact, functional ryanodine receptors t...

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Veröffentlicht in:J Biol Chem
Hauptverfasser: Rebbeck, Robyn T., Nitu, Florentin R., Rohde, David, Most, Patrick, Bers, Donald M., Thomas, David D., Cornea, Razvan L.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2016
Schlagworte:
Molecular Biophysics
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4957069/
https://ncbi.nlm.nih.gov/pubmed/27226555
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.713107
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