Adult hematopoietic stem cells lacking Hif-1α self-renew normally

The hematopoietic stem cell (HSC) pool is maintained under hypoxic conditions within the bone marrow microenvironment. Cellular responses to hypoxia are largely mediated by the hypoxia-inducible factors, Hif-1 and Hif-2. The oxygen-regulated α subunits of Hif-1 and Hif-2 (namely, Hif-1α and Hif-2α)...

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Vydáno v:Blood
Hlavní autoři: Vukovic, Milica, Sepulveda, Catarina, Subramani, Chithra, Guitart, Amélie V., Mohr, Jasmine, Allen, Lewis, Panagopoulou, Theano I., Paris, Jasmin, Lawson, Hannah, Villacreces, Arnaud, Armesilla-Diaz, Alejandro, Gezer, Deniz, Holyoake, Tessa L., Ratcliffe, Peter J., Kranc, Kamil R.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society of Hematology 2016
Témata:
Hematopoiesis and Stem Cells
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4956613/
https://ncbi.nlm.nih.gov/pubmed/27060169
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2015-10-677138
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