Deregulated Methionine Adenosyltransferase α1, c-Myc and Maf Proteins Interplay Promotes Cholangiocarcinoma Growth in Mice and Humans

We reported c-Myc induction drives cholestatic liver injury and cholangiocarcinoma (CCA) in mice. We also showed induction of Maf proteins (MafG and c-Maf) contributed to cholestatic liver injury, whereas S-adenosylmethionine (SAMe) administration was protective. Here we determined whether there is...

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Publicado en:Hepatology
Main Authors: Yang, Heping, Liu, Ting, Wang, Jiaohong, Li, Tony W.H., Fan, Wei, Peng, Hui, Krishnan, Anuradha, Gores, Gregory J., Mato, Jose M., Lu, Shelly C.
Formato: Artigo
Idioma:Inglês
Publicado: 2016
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4956551/
https://ncbi.nlm.nih.gov/pubmed/26969892
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/hep.28541
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