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Validating Endpoints for Therapeutic Trials in Fecal Incontinence

BACKGROUND: A 50% or greater reduction in the frequency of fecal incontinence (FI) recorded with daily bowel diaries is the primary endpoint in clinical trials of FI. Whether this difference is clinically important is unknown. The relationship between FI symptoms recorded with daily and weekly instr...

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Pubblicato in:Neurogastroenterol Motil
Autori principali: Noelting, Jessica, Zinsmeister, Alan R., Bharucha, Adil E.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2016
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4956545/
https://ncbi.nlm.nih.gov/pubmed/26948292
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/nmo.12809
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