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Validating Endpoints for Therapeutic Trials in Fecal Incontinence

BACKGROUND: A 50% or greater reduction in the frequency of fecal incontinence (FI) recorded with daily bowel diaries is the primary endpoint in clinical trials of FI. Whether this difference is clinically important is unknown. The relationship between FI symptoms recorded with daily and weekly instr...

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Detalhes bibliográficos
Publicado no:Neurogastroenterol Motil
Main Authors: Noelting, Jessica, Zinsmeister, Alan R., Bharucha, Adil E.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4956545/
https://ncbi.nlm.nih.gov/pubmed/26948292
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/nmo.12809
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