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Validating Endpoints for Therapeutic Trials in Fecal Incontinence

BACKGROUND: A 50% or greater reduction in the frequency of fecal incontinence (FI) recorded with daily bowel diaries is the primary endpoint in clinical trials of FI. Whether this difference is clinically important is unknown. The relationship between FI symptoms recorded with daily and weekly instr...

Ausführliche Beschreibung

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Veröffentlicht in:Neurogastroenterol Motil
Hauptverfasser: Noelting, Jessica, Zinsmeister, Alan R., Bharucha, Adil E.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2016
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4956545/
https://ncbi.nlm.nih.gov/pubmed/26948292
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/nmo.12809
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