Mixed Phenotype Acute Leukemia (MPAL) Exhibits Frequent Mutations in DNMT3A and Activated Signaling Genes

Mixed phenotype acute leukemia (MPAL) is a heterogeneous group of poor-prognosis leukemias with immunophenotypic features of at least two cell lineages. The full spectrum of genetic mutations in this rare disease has not been elucidated, limiting our understanding of disease pathogenesis and our abi...

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Gepubliceerd in:Exp Hematol
Hoofdauteurs: Eckstein, Olive S., Wang, Linghua, Punia, Jyotinder N., Kornblau, Steven M., Andreeff, Michael, Wheeler, David A., Goodell, Margaret A., Rau, Rachel E.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2016
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4956537/
https://ncbi.nlm.nih.gov/pubmed/27208809
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.exphem.2016.05.003
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