Carregant...
Obligate coupling of CFTR pore opening to tight nucleotide-binding domain dimerization
In CFTR, the chloride channel mutated in cystic fibrosis (CF) patients, ATP-binding-induced dimerization of two cytosolic nucleotide binding domains (NBDs) opens the pore, and dimer disruption following ATP hydrolysis closes it. Spontaneous openings without ATP are rare in wild-type CFTR, but in cer...
Guardat en:
| Publicat a: | eLife |
|---|---|
| Autors principals: | , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
eLife Sciences Publications, Ltd
2016
|
| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4956468/ https://ncbi.nlm.nih.gov/pubmed/27328319 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.18164 |
| Etiquetes: |
Afegir etiqueta
Sense etiquetes, Sigues el primer a etiquetar aquest registre!
|