Deficiency of Nuclear Factor-κB c-Rel Accelerates the Development of Autoimmune Diabetes in NOD Mice

The nuclear factor-κB protein c-Rel plays a critical role in controlling autoimmunity. c-Rel–deficient mice are resistant to streptozotocin-induced diabetes, a drug-induced model of autoimmune diabetes. We generated c-Rel–deficient NOD mice to examine the role of c-Rel in the development of spontane...

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Detalhes bibliográficos
Publicado no:Diabetes
Main Authors: Ramakrishnan, Parameswaran, Yui, Mary A., Tomalka, Jeffrey A., Majumdar, Devdoot, Parameswaran, Reshmi, Baltimore, David
Formato: Artigo
Idioma:Inglês
Publicado em: American Diabetes Association 2016
Assuntos:
Immunology and Transplantation
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4955991/
https://ncbi.nlm.nih.gov/pubmed/27217485
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db15-1607
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