NF-κB c-Rel Is Dispensable for the Development but Is Required for the Cytotoxic Function of NK Cells

Natural Killer (NK) cells are cytotoxic lymphocytes critical to the innate immune system. We found that germline deficiency of NF-κB c-Rel results in a marked decrease in cytotoxic function of NK cells, both in vitro and in vivo, with no significant differences in the stages of NK cell development....

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Detalhes bibliográficos
Publicado no:Front Immunol
Main Authors: Vicioso, Yorleny, Wong, Derek P., Roy, Nand K., Das, Nayanika, Zhang, Keman, Ramakrishnan, Parameswaran, Parameswaran, Reshmi
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2021
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8116710/
https://ncbi.nlm.nih.gov/pubmed/33995369
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2021.652786
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