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(−)-RHAZINILAM AND THE DIPHENYLPYRIDAZINONE NSC 613241: TWO COMPOUNDS INDUCING THE FORMATION OF MORPHOLOGICALLY SIMILAR TUBULIN SPIRALS BUT BINDING APPARENTLY TO TWO DISTINCT SITES ON TUBULIN(,)
The most potent microtubule assembly inhibitor of newer diphenylpyridazinone derivatives examined was NSC 613241. Because NSC 613241 and (−)-rhazinilam also induce the formation of similar 2-filament spirals, these aberrant reactions were compared. Spiral formation with both compounds was enhanced b...
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| 出版年: | Arch Biochem Biophys |
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| 主要な著者: | , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2016
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4955782/ https://ncbi.nlm.nih.gov/pubmed/27311615 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.abb.2016.06.008 |
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