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RIBOSE MODIFIED NUCLEOSIDES AND NUCLEOTIDES AS LIGANDS FOR PURINE RECEPTORS

Molecular modeling of receptors for adenosine and nucleotide (P2) receptors with docked ligand, based on mutagenesis, was carried out. Adenosine 3(′),5(′)-bisphosphate derivatives act as selective P2Y(1) antagonists/partial agonists. The ribose moiety was replaced with carbocyclics, smaller and larg...

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Détails bibliographiques
Publié dans:Nucleosides Nucleotides Nucleic Acids
Auteurs principaux: Jacobson, K. A., Ravi, R. G., Nandanan, E., Kim, H. S., Moro, S., Kim, Y. C., Lee, K., Barak, D., Marquez, V. E., Ji, X. D.
Format: Artigo
Langue:Inglês
Publié: 2001
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4955583/
https://ncbi.nlm.nih.gov/pubmed/11563046
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1081/NCN-100002305
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