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RIBOSE MODIFIED NUCLEOSIDES AND NUCLEOTIDES AS LIGANDS FOR PURINE RECEPTORS
Molecular modeling of receptors for adenosine and nucleotide (P2) receptors with docked ligand, based on mutagenesis, was carried out. Adenosine 3(′),5(′)-bisphosphate derivatives act as selective P2Y(1) antagonists/partial agonists. The ribose moiety was replaced with carbocyclics, smaller and larg...
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| Publicado en: | Nucleosides Nucleotides Nucleic Acids |
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| Main Authors: | , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2001
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4955583/ https://ncbi.nlm.nih.gov/pubmed/11563046 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1081/NCN-100002305 |
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