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High-Resolution PET Imaging with Therapeutic Antibody-based PD-1/PD-L1 Checkpoint Tracers

Checkpoint-blocking antibodies like those targeting the PD-1/PD-L1 pathway have revolutionized oncology. We developed radiotracers based on therapeutic checkpoint-blocking antibodies permitting sensitive and high-resolution PET imaging of both PD-1 and PD-L1 in immunocompetent mice. ImmunoPET of nai...

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Detalhes bibliográficos
Publicado no:Theranostics
Main Authors: Hettich, Michael, Braun, Friederike, Bartholomä, Mark D., Schirmbeck, Reinhold, Niedermann, Gabriele
Formato: Artigo
Idioma:Inglês
Publicado em: Ivyspring International Publisher 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4955062/
https://ncbi.nlm.nih.gov/pubmed/27446497
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7150/thno.15253
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