Endogenous interleukin‐22 protects against inflammatory bowel disease but not autoimmune cholangitis in dominant negative form of transforming growth factor beta receptor type II mice

During chronic inflammation, interleukin (IL)‐22 expression is up‐regulated in both CD4 and CD8 T cells, exerting a protective role in infections. However, in autoimmunity, IL‐22 appears to have either a protective or a pathogenic role in a variety of murine models of autoimmunity and, by extrapolat...

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Bibliografiske detaljer
Udgivet i:Clin Exp Immunol
Main Authors: Yang, G.‐X., Sun, Y., Tsuneyama, K., Zhang, W., Leung, P. S. C., He, X.‐S., Ansari, A. A., Bowlus, C., Ridgway, W. M., Gershwin, M. E.
Format: Artigo
Sprog:Inglês
Udgivet: John Wiley and Sons Inc. 2016
Fag:
Original Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4955007/
https://ncbi.nlm.nih.gov/pubmed/27148790
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/cei.12806
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