Human islets and dendritic cells generate post‐translationally modified islet autoantigens

The initiation of type 1 diabetes (T1D) requires a break in peripheral tolerance. New insights into neoepitope formation indicate that post‐translational modification of islet autoantigens, for example via deamidation, may be an important component of disease initiation or exacerbation. Indeed, deam...

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Publicat a:Clin Exp Immunol
Autors principals: McLaughlin, R. J., de Haan, A., Zaldumbide, A., de Koning, E. J., de Ru, A. H., van Veelen, P. A., van Lummel, M., Roep, B. O.
Format: Artigo
Idioma:Inglês
Publicat: John Wiley and Sons Inc. 2016
Matèries:
Original Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4955000/
https://ncbi.nlm.nih.gov/pubmed/26861694
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/cei.12775
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