Type 1 Diabetes-associated HLA-DQ8 Transdimer Accommodates a Unique Peptide Repertoire

HLA-DQ2 and HLA-DQ8 are strongly predisposing haplotypes for type 1 diabetes (T1D). Yet HLA-DQ2/8 heterozygous individuals have a synergistically increased risk compared with HLA-DQ2 or HLA-DQ8 homozygote subjects that may result from the presence of a transdimer formed between the α-chain of HLA-DQ...

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Detalhes bibliográficos
Main Authors: van Lummel, Menno, van Veelen, Peter A., Zaldumbide, Arnaud, de Ru, Arnoud, Janssen, George M. C., Moustakas, Antonis K., Papadopoulos, George K., Drijfhout, Jan W., Roep, Bart O., Koning, Frits
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2012
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3308765/
https://ncbi.nlm.nih.gov/pubmed/22184118
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.313940
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