Sterol Biosynthesis and Azole Tolerance Is Governed by the Opposing Actions of SrbA and the CCAAT Binding Complex

Azole drugs selectively target fungal sterol biosynthesis and are critical to our antifungal therapeutic arsenal. However, resistance to this class of drugs, particularly in the major human mould pathogen Aspergillus fumigatus, is emerging and reaching levels that have prompted some to suggest that...

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שמור ב:
מידע ביבליוגרפי
הוצא לאור ב:PLoS Pathog
Main Authors: Gsaller, Fabio, Hortschansky, Peter, Furukawa, Takanori, Carr, Paul D., Rash, Bharat, Capilla, Javier, Müller, Christoph, Bracher, Franz, Bowyer, Paul, Haas, Hubertus, Brakhage, Axel A., Bromley, Michael J.
פורמט: Artigo
שפה:Inglês
יצא לאור: Public Library of Science 2016
נושאים:
Research Article
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC4954732/
https://ncbi.nlm.nih.gov/pubmed/27438727
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1005775
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