Ribosomal protein S6 kinase 1 signaling regulates mammalian lifespan

Caloric restriction (CR) protects against aging and disease but the mechanisms by which this affects mammalian lifespan are unclear. We show in mice that deletion of the nutrient-responsive mTOR (mammalian target of rapamycin) signaling pathway component ribosomal S6 protein kinase 1 (S6K1) led to i...

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Publicat a:Science
Autors principals: Selman, Colin, Tullet, Jennifer M.A., Wieser, Daniela, Irvine, Elaine, Lingard, Steven J., Choudhury, Agharul I., Claret, Marc, Al-Qassab, Hind, Carmignac, Danielle, Ramadani, Faruk, Woods, Angela, Robinson, Iain C.A., Schuster, Eugene, Batterham, Rachel L., Kozma, Sara C., Thomas, George, Carling, David, Okkenhaug, Klaus, Thornton, Janet M., Partridge, Linda, Gems, David, Withers, Dominic J.
Format: Artigo
Idioma:Inglês
Publicat: 2009
Matèries:
Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4954603/
https://ncbi.nlm.nih.gov/pubmed/19797661
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1177221
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