Targeted genomic analysis reveals widespread autoimmune disease association with regulatory variants in the TNF superfamily cytokine signalling network

BACKGROUND: Tumour necrosis factor (TNF) superfamily cytokines and their receptors regulate diverse immune system functions through a common set of signalling pathways. Genetic variants in and expression of individual TNF superfamily cytokines, receptors and signalling proteins have been associated...

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Detalhes bibliográficos
Publicado no:Genome Med
Main Authors: Richard, Arianne C., Peters, James E., Lee, James C., Vahedi, Golnaz, Schäffer, Alejandro A., Siegel, Richard M., Lyons, Paul A., Smith, Kenneth G. C.
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2016
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4952362/
https://ncbi.nlm.nih.gov/pubmed/27435189
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13073-016-0329-5
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