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Molecular mousetraps, α(1)-antitrypsin deficiency and the serpinopathies
Point mutations in members of the serine proteinase inhibitor or serpin superfamily cause them to change shape, polymerise and be deposited in the tissues. This process is best seen in mutants of α(1)-antitrypsin within hepatocytes to cause periodic acid-Schiff (PAS) positive inclusions and cirrhosi...
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| Publicado no: | Clin Med (Lond) |
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| Autor principal: | |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Royal College of Physicians
2005
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4952210/ https://ncbi.nlm.nih.gov/pubmed/16011217 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7861/clinmedicine.5-3-249 |
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