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Molecular mousetraps, α(1)-antitrypsin deficiency and the serpinopathies
Point mutations in members of the serine proteinase inhibitor or serpin superfamily cause them to change shape, polymerise and be deposited in the tissues. This process is best seen in mutants of α(1)-antitrypsin within hepatocytes to cause periodic acid-Schiff (PAS) positive inclusions and cirrhosi...
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| Publicado en: | Clin Med (Lond) |
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| Autor Principal: | |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
Royal College of Physicians
2005
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4952210/ https://ncbi.nlm.nih.gov/pubmed/16011217 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7861/clinmedicine.5-3-249 |
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