Depressive symptoms as a side effect of Interferon-α therapy induced by induction of indoleamine 2,3-dioxygenase 1

Depression is known to occur frequently in chronic hepatitis C viral (HCV) patients receiving interferon (IFN)-α therapy. In this study, we investigated whether indoleamine 2,3-dioxygenase1 (IDO1)-mediated tryptophan (TRP) metabolism plays a critical role in depression occurring as a side effect of...

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Udgivet i:Sci Rep
Main Authors: Murakami, Yuki, Ishibashi, Takaaki, Tomita, Eiichi, Imamura, Yukio, Tashiro, Tomoyuki, Watcharanurak, Kanitta, Nishikawa, Makiya, Takahashi, Yuki, Takakura, Yoshinobu, Mitani, Satoko, Fujigaki, Hidetsugu, Ohta, Yoshiji, Kubo, Hisako, Mamiya, Takayoshi, Nabeshima, Toshitaka, Kim, Hyoung-Chun, Yamamoto, Yasuko, Saito, Kuniaki
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2016
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4951771/
https://ncbi.nlm.nih.gov/pubmed/27436416
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep29920
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