Methylomes of renal cell lines and tumors or metastases differ significantly with impact on pharmacogenes

Current therapies for metastatic clear cell renal cell carcinoma (ccRCC) show limited efficacy. Drug efficacy, typically investigated in preclinical cell line models during drug development, is influenced by pharmacogenes involved in targeting and disposition of drugs. Here we show through genome-wi...

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Udgivet i:Sci Rep
Main Authors: Winter, Stefan, Fisel, Pascale, Büttner, Florian, Rausch, Steffen, D’Amico, Debora, Hennenlotter, Jörg, Kruck, Stephan, Nies, Anne T., Stenzl, Arnulf, Junker, Kerstin, Scharpf, Marcus, Hofmann, Ute, van der Kuip, Heiko, Fend, Falko, Ott, German, Agaimy, Abbas, Hartmann, Arndt, Bedke, Jens, Schwab, Matthias, Schaeffeler, Elke
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2016
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4951699/
https://ncbi.nlm.nih.gov/pubmed/27435027
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep29930
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