Methylomes of renal cell lines and tumors or metastases differ significantly with impact on pharmacogenes

Current therapies for metastatic clear cell renal cell carcinoma (ccRCC) show limited efficacy. Drug efficacy, typically investigated in preclinical cell line models during drug development, is influenced by pharmacogenes involved in targeting and disposition of drugs. Here we show through genome-wi...

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Detaylı Bibliyografya
Yayımlandı:Sci Rep
Asıl Yazarlar: Winter, Stefan, Fisel, Pascale, Büttner, Florian, Rausch, Steffen, D’Amico, Debora, Hennenlotter, Jörg, Kruck, Stephan, Nies, Anne T., Stenzl, Arnulf, Junker, Kerstin, Scharpf, Marcus, Hofmann, Ute, van der Kuip, Heiko, Fend, Falko, Ott, German, Agaimy, Abbas, Hartmann, Arndt, Bedke, Jens, Schwab, Matthias, Schaeffeler, Elke
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Nature Publishing Group 2016
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4951699/
https://ncbi.nlm.nih.gov/pubmed/27435027
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep29930
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