Transformation of the tumour microenvironment by a CD40 agonist antibody correlates with improved responses to PD-L1 blockade in a mouse orthotopic pancreatic tumour model

Despite the availability of recently developed chemotherapy regimens, survival times for pancreatic cancer patients remain poor. These patients also respond poorly to immune checkpoint blockade therapies (anti-CTLA-4, anti-PD-L1, anti-PD-1), which suggests the presence of additional immunosuppressiv...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Luheshi, Nadia M., Coates-Ulrichsen, Jane, Harper, James, Mullins, Stefanie, Sulikowski, Michal G., Martin, Philip, Brown, Lee, Lewis, Arthur, Davies, Gareth, Morrow, Michelle, Wilkinson, Robert W.
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2016
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4951305/
https://ncbi.nlm.nih.gov/pubmed/26918344
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.7610
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