T cells conditioned with MDSC show an increased anti-tumor activity after adoptive T cell based immunotherapy

The success of adoptive T cell-based immunotherapy (ACT) in cancer is limited in part by the accumulation of myeloid-derived suppressor cells (MDSC), which block several T cell functions, including T cell proliferation and the expression of various cytotoxic mediators. Paradoxically, the inhibition...

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Détails bibliographiques
Publié dans:Oncotarget
Auteurs principaux: Raber, Patrick L., Sierra, Rosa A., Thevenot, Paul T., Shuzhong, Zhang, Wyczechowska, Dorota D., Kumai, Takumi, Celis, Esteban, Rodriguez, Paulo C.
Format: Artigo
Langue:Inglês
Publié: Impact Journals LLC 2016
Sujets:
Research Paper: Immunology
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4951233/
https://ncbi.nlm.nih.gov/pubmed/27007050
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.8197
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