Fasting-Induced Changes in Hepatic P450 Mediated Drug Metabolism Are Largely Independent of the Constitutive Androstane Receptor CAR

INTRODUCTION: Hepatic drug metabolism by cytochrome P450 enzymes is altered by the nutritional status of patients. The expression of P450 enzymes is partly regulated by the constitutive androstane receptor (CAR). Fasting regulates the expression of both P450 enzymes and CAR and affects hepatic drug...

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Publicado no:PLoS One
Main Authors: de Vries, E. M., Lammers, L. A., Achterbergh, R., Klümpen, H-J, Mathot, R. A. A., Boelen, A., Romijn, J. A.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2016
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4951123/
https://ncbi.nlm.nih.gov/pubmed/27434302
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0159552
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