Fasting-Induced Changes in Hepatic P450 Mediated Drug Metabolism Are Largely Independent of the Constitutive Androstane Receptor CAR

INTRODUCTION: Hepatic drug metabolism by cytochrome P450 enzymes is altered by the nutritional status of patients. The expression of P450 enzymes is partly regulated by the constitutive androstane receptor (CAR). Fasting regulates the expression of both P450 enzymes and CAR and affects hepatic drug...

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Bibliografische gegevens
Gepubliceerd in:PLoS One
Hoofdauteurs: de Vries, E. M., Lammers, L. A., Achterbergh, R., Klümpen, H-J, Mathot, R. A. A., Boelen, A., Romijn, J. A.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Public Library of Science 2016
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Research Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4951123/
https://ncbi.nlm.nih.gov/pubmed/27434302
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0159552
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