Human intrahepatic regulatory T cells are functional, require IL‐2 from effector cells for survival, and are susceptible to Fas ligand‐mediated apoptosis

Regulatory T cells (T(reg)) suppress T effector cell proliferation and maintain immune homeostasis. Autoimmune liver diseases persist despite high frequencies of T(reg) in the liver, suggesting that the local hepatic microenvironment might affect T(reg) stability, survival, and function. We hypothes...

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Dades bibliogràfiques
Publicat a:Hepatology
Autors principals: Chen, Yung‐Yi, Jeffery, Hannah C., Hunter, Stuart, Bhogal, Ricky, Birtwistle, Jane, Braitch, Manjit Kaur, Roberts, Sheree, Ming, Mikaela, Hannah, Jack, Thomas, Clare, Adali, Gupse, Hübscher, Stefan G., Syn, Wing‐Kin, Afford, Simon, Lalor, Patricia F., Adams, David H., Oo, Ye H.
Format: Artigo
Idioma:Inglês
Publicat: John Wiley and Sons Inc. 2016
Matèries:
Autoimmune, Cholestatic and Biliary Disease
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4950043/
https://ncbi.nlm.nih.gov/pubmed/26928938
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/hep.28517
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