Human intrahepatic regulatory T cells are functional, require IL‐2 from effector cells for survival, and are susceptible to Fas ligand‐mediated apoptosis

Regulatory T cells (T(reg)) suppress T effector cell proliferation and maintain immune homeostasis. Autoimmune liver diseases persist despite high frequencies of T(reg) in the liver, suggesting that the local hepatic microenvironment might affect T(reg) stability, survival, and function. We hypothes...

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Bibliografske podrobnosti
izdano v:Hepatology
Main Authors: Chen, Yung‐Yi, Jeffery, Hannah C., Hunter, Stuart, Bhogal, Ricky, Birtwistle, Jane, Braitch, Manjit Kaur, Roberts, Sheree, Ming, Mikaela, Hannah, Jack, Thomas, Clare, Adali, Gupse, Hübscher, Stefan G., Syn, Wing‐Kin, Afford, Simon, Lalor, Patricia F., Adams, David H., Oo, Ye H.
Format: Artigo
Jezik:Inglês
Izdano: John Wiley and Sons Inc. 2016
Teme:
Autoimmune, Cholestatic and Biliary Disease
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4950043/
https://ncbi.nlm.nih.gov/pubmed/26928938
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/hep.28517
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