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Combined in vitro transcription and reverse transcription to amplify and label complex synthetic oligonucleotide probe libraries

Oligonucleotide microarrays allow the production of complex custom oligonucleotide libraries for nucleic acid detection–based applications such as fluorescence in situ hybridization (FISH). We have developed a PCR-free method to make single-stranded DNA (ssDNA) fluorescent probes through an intermed...

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Detalhes bibliográficos
Publicado no:Biotechniques
Main Authors: Murgha, Yusuf, Beliveau, Brian, Semrau, Kassandra, Schwartz, Donald, Wu, Chao-ting, Gulari, Erdogan, Rouillard, Jean-Marie
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4949592/
https://ncbi.nlm.nih.gov/pubmed/26054766
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2144/000114298
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