Bacterial β-Glucosidase Reveals the Structural and Functional Basis of Genetic Defects in Human Glucocerebrosidase 2 (GBA2)

[Image: see text] Human glucosylcerebrosidase 2 (GBA2) of the CAZy family GH116 is responsible for the breakdown of glycosphingolipids on the cytoplasmic face of the endoplasmic reticulum and Golgi apparatus. Genetic defects in GBA2 result in spastic paraplegia and cerebellar ataxia, while cross-tal...

詳細記述

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書誌詳細
出版年:ACS Chem Biol
主要な著者: Charoenwattanasatien, Ratana, Pengthaisong, Salila, Breen, Imogen, Mutoh, Risa, Sansenya, Sompong, Hua, Yanling, Tankrathok, Anupong, Wu, Liang, Songsiriritthigul, Chomphunuch, Tanaka, Hideaki, Williams, Spencer J., Davies, Gideon J., Kurisu, Genji, Cairns, James R. Ketudat
フォーマット: Artigo
言語:Inglês
出版事項: American Chemical Society 2016
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC4949581/
https://ncbi.nlm.nih.gov/pubmed/27115290
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschembio.6b00192
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