Bacterial β-Glucosidase Reveals the Structural and Functional Basis of Genetic Defects in Human Glucocerebrosidase 2 (GBA2)

[Image: see text] Human glucosylcerebrosidase 2 (GBA2) of the CAZy family GH116 is responsible for the breakdown of glycosphingolipids on the cytoplasmic face of the endoplasmic reticulum and Golgi apparatus. Genetic defects in GBA2 result in spastic paraplegia and cerebellar ataxia, while cross-tal...

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Detalhes bibliográficos
Publicado no:ACS Chem Biol
Main Authors: Charoenwattanasatien, Ratana, Pengthaisong, Salila, Breen, Imogen, Mutoh, Risa, Sansenya, Sompong, Hua, Yanling, Tankrathok, Anupong, Wu, Liang, Songsiriritthigul, Chomphunuch, Tanaka, Hideaki, Williams, Spencer J., Davies, Gideon J., Kurisu, Genji, Cairns, James R. Ketudat
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2016
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4949581/
https://ncbi.nlm.nih.gov/pubmed/27115290
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschembio.6b00192
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