Engineering Factor Xa Inhibitor with Multiple Platelet-Binding Sites Facilitates its Platelet Targeting

Targeted delivery of antithrombotic drugs centralizes the effects in the thrombosis site and reduces the hemorrhage side effects in uninjured vessels. We have recently reported that the platelet-targeting factor Xa (FXa) inhibitors, constructed by engineering one Arg-Gly-Asp (RGD) motif into Ancylos...

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Detaylı Bibliyografya
Yayımlandı:Sci Rep
Asıl Yazarlar: Zhu, Yuanjun, Li, Ruyi, Lin, Yuan, Shui, Mengyang, Liu, Xiaoyan, Chen, Huan, Wang, Yinye
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Nature Publishing Group 2016
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4949463/
https://ncbi.nlm.nih.gov/pubmed/27432161
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep29895
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