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Toward the mechanism of eIF4F-mediated ribosomal attachment to mammalian capped mRNAs

Ribosomal attachment to mammalian capped mRNAs is achieved through the cap–eukaryotic initiation factor 4E (eIF4E)–eIF4G–eIF3–40S chain of interactions, but the mechanism by which mRNA enters the mRNA-binding channel of the 40S subunit remains unknown. To investigate this process, we recapitulated i...

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Publicado en:Genes Dev
Main Authors: Kumar, Parimal, Hellen, Christopher U.T., Pestova, Tatyana V.
Formato: Artigo
Idioma:Inglês
Publicado: Cold Spring Harbor Laboratory Press 2016
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4949329/
https://ncbi.nlm.nih.gov/pubmed/27401559
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.282418.116
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