Toward the mechanism of eIF4F-mediated ribosomal attachment to mammalian capped mRNAs

Ribosomal attachment to mammalian capped mRNAs is achieved through the cap–eukaryotic initiation factor 4E (eIF4E)–eIF4G–eIF3–40S chain of interactions, but the mechanism by which mRNA enters the mRNA-binding channel of the 40S subunit remains unknown. To investigate this process, we recapitulated i...

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Bibliografiske detaljer
Udgivet i:Genes Dev
Main Authors: Kumar, Parimal, Hellen, Christopher U.T., Pestova, Tatyana V.
Format: Artigo
Sprog:Inglês
Udgivet: Cold Spring Harbor Laboratory Press 2016
Fag:
Research Paper
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4949329/
https://ncbi.nlm.nih.gov/pubmed/27401559
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.282418.116
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