Decreased SMG7 expression associates with lupus-risk variants and elevated antinuclear antibody production

OBJECTIVES: Following up the SLE GWAS identification of NMNAT2 at rs2022013, we fine-mapped its 150kb flanking regions containing NMNAT2 and SMG7 in a 15,292 case-control multi-ancestry population and tested functions of identified variants. METHODS: We performed genotyping using custom array, imput...

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Detalhes bibliográficos
Publicado no:Ann Rheum Dis
Main Authors: Deng, Yun, Zhao, Jian, Sakurai, Daisuke, Sestak, Andrea L., Osadchiy, Vadim, Langefeld, Carl D., Kaufman, Kenneth M., Kelly, Jennifer A., James, Judith A., Petri, Michelle A., Bae, Sang-Cheol, Alarcón-Riquelme, Marta E., Alarcón, Graciela S, Anaya, Juan-Manuel, Criswell, Lindsey A., Freedman, Barry I, Kamen, Diane L., Gilkeson, Gary S., Jacob, Chaim O., Merrill, Joan T, Gaffney, Patrick M., Sivils, Kathy Moser, Niewold, Timothy B, Ramsey-Goldman, Rosalind, Reveille, John D, Scofield, R Hal, Stevens, Anne M, Boackle, Susan A, Vilá, Luis M, Sohn, Woong, Lee, Seung, Chang, Deh-Ming, Song, Yeong Wook, Vyse, Timothy J., Harley, John B., Brown, Elizabeth E., Edberg, Jeffrey C., Kimberly, Robert P., Cantor, Rita M., Hahn, Bevra H., Grossman, Jennifer M., Tsao, Betty P.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4949149/
https://ncbi.nlm.nih.gov/pubmed/26783109
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/annrheumdis-2015-208441
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