Preferential Binding to Elk-1 by SLE-Associated IL10 Risk Allele Upregulates IL10 Expression

Immunoregulatory cytokine interleukin-10 (IL-10) is elevated in sera from patients with systemic lupus erythematosus (SLE) correlating with disease activity. The established association of IL10 with SLE and other autoimmune diseases led us to fine map causal variant(s) and to explore underlying mech...

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Main Authors: Sakurai, Daisuke, Zhao, Jian, Deng, Yun, Kelly, Jennifer A., Brown, Elizabeth E., Harley, John B., Bae, Sang-Cheol, Alarcόn-Riquelme, Marta E., Edberg, Jeffrey C., Kimberly, Robert P., Ramsey-Goldman, Rosalind, Petri, Michelle A., Reveille, John D., Vilá, Luis M., Alarcón, Graciela S., Kaufman, Kenneth M., Vyse, Timothy J., Jacob, Chaim O., Gaffney, Patrick M., Sivils, Kathy Moser, James, Judith A., Kamen, Diane L., Gilkeson, Gary S., Niewold, Timothy B., Merrill, Joan T., Scofield, R. Hal, Criswell, Lindsey A., Stevens, Anne M., Boackle, Susan A., Kim, Jae-Hoon, Choi, Jiyoung, Pons-Estel, Bernardo A., Freedman, Barry I., Anaya, Juan-Manuel, Martin, Javier, Yu, C. Yung, Chang, Deh-Ming, Song, Yeong Wook, Langefeld, Carl D., Chen, Weiling, Grossman, Jennifer M., Cantor, Rita M., Hahn, Bevra H., Tsao, Betty P.
格式: Artigo
語言:Inglês
出版: Public Library of Science 2013
主題:
Research Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3794920/
https://ncbi.nlm.nih.gov/pubmed/24130510
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1003870
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