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Delayed MEK/ERK Inhibition by Trametinib Attenuates Systemic Inflammatory Responses and Multi-Organ Injury in Murine Sepsis
OBJECTIVE: The MEK/ERK signaling pathway is an essential component of innate immunity necessary for mediating pro-inflammatory responses in the setting of sepsis. We previously demonstrated that the MEK1/2 inhibitor trametinib, prevents endotoxin-induced renal injury in mice. We therefore assessed e...
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| Publié dans: | Crit Care Med |
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| Auteurs principaux: | , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
2016
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4949133/ https://ncbi.nlm.nih.gov/pubmed/27031380 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/CCM.0000000000001672 |
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