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Heme Oxygenase Activity and Hemoglobin Neurotoxicity Are Attenuated by Inhibitors of the MEK/ERK Pathway
Hemoglobin breakdown produces an iron-dependent neuronal injury after experimental CNS hemorrhage that may be attenuated by heme oxygenase (HO) inhibitors. The HO enzymes are phosphoproteins that are activated by phosphorylation in vitro. While testing the effect of kinase inhibitors in cortical cel...
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| Autores principales: | , , , , |
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
2009
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2692087/ https://ncbi.nlm.nih.gov/pubmed/19371583 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuropharm.2009.01.022 |
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