Heme Oxygenase Activity and Hemoglobin Neurotoxicity Are Attenuated by Inhibitors of the MEK/ERK Pathway

Hemoglobin breakdown produces an iron-dependent neuronal injury after experimental CNS hemorrhage that may be attenuated by heme oxygenase (HO) inhibitors. The HO enzymes are phosphoproteins that are activated by phosphorylation in vitro. While testing the effect of kinase inhibitors in cortical cel...

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Main Authors: Chen-Roetling, Jing, Li, Zhi, Chen, Mai, Awe, Olatilewa O., Regan, Raymond F.
Format: Artigo
Sprog:Inglês
Udgivet: 2009
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2692087/
https://ncbi.nlm.nih.gov/pubmed/19371583
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuropharm.2009.01.022
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