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Control of Ion Selectivity in LeuT: Two Na(+) Binding Sites with two different mechanisms

The x-ray structure of LeuT, a bacterial homologue of Na(+)/Cl(−)-dependent neurotransmitter transporter, provides a great opportunity to better understand the molecular basis of monovalent cation selectivity in ion-coupled transporters. LeuT possesses two ion-binding sites, NA1 and NA2, which are h...

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Publicat a:J Mol Biol
Autors principals: Noskov, Sergei Y., Roux, Benoît
Format: Artigo
Idioma:Inglês
Publicat: 2008
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4948944/
https://ncbi.nlm.nih.gov/pubmed/18280500
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2008.01.015
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