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PARP Inhibitors in Clinical Use Induce Genomic Instability in Normal Human Cells
Poly(ADP-ribose) polymerases (PARPs) are the first proteins involved in cellular DNA repair pathways to be targeted by specific inhibitors for clinical benefit. Tumors harboring genetic defects in homologous recombination (HR), a DNA double-strand break (DSB) repair pathway, are hypersensitive to PA...
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| Publicado no: | PLoS One |
|---|---|
| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Public Library of Science
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4948780/ https://ncbi.nlm.nih.gov/pubmed/27428646 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0159341 |
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