CCT241533 is a potent and selective inhibitor of CHK2 which potentiates the cytotoxicity of PARP inhibitors

CHK2 is a checkpoint kinase involved in the ATM-mediated response to double strand DNA breaks. Its potential as a drug target is still unclear but inhibitors of CHK2 may increase the efficacy of genotoxic cancer therapies in a p53 mutant background by eliminating one of the checkpoints or DNA repair...

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Vydáno v:Cancer Res
Hlavní autoři: Anderson, Victoria E, Walton, Michael I, Eve, Paul D, Boxall, Katherine J, Antoni, Laurent, Caldwell, John J, Pearl, Laurence H, Oliver, Antony W, Collins, Ian, Garrett, Michelle D
Médium: Artigo
Jazyk:Inglês
Vydáno: 2011
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4948722/
https://ncbi.nlm.nih.gov/pubmed/21239475
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-10-1252
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