CCT241533 is a potent and selective inhibitor of CHK2 which potentiates the cytotoxicity of PARP inhibitors

Lignende værker

• CCT244747 is a novel, potent and selective CHK1 inhibitor with oral efficacy alone and in combination with genotoxic anticancer drugs
  af: Walton, Mike I, et al.
  Udgivet: (2012)
• Preclinical pharmacology, antitumor activity and development of pharmacodynamic markers for the novel, potent AKT inhibitor CCT128930
  af: Yap, Timothy A., et al.
  Udgivet: (2010)
• Structure-Guided Evolution of Potent and Selective CHK1 Inhibitors through Scaffold Morphing
  af: Reader, John C., et al.
  Udgivet: (2011)
• The clinical development candidate CCT245737 is an orally active CHK1 inhibitor with preclinical activity in RAS mutant NSCLC and Eμ-MYC driven B-cell lymphoma
  af: Walton, Mike I., et al.
  Udgivet: (2015)
• Molecular profiling and combinatorial activity of CCT068127: a potent CDK2 and CDK9 inhibitor
  af: Whittaker, Steven R., et al.
  Udgivet: (2018)