SHANK3 controls maturation of social reward circuits in the VTA

Haploinsufficiency of SHANK3, encoding the synapse scaffolding protein SHANK3, leads to a highly penetrant form of Autism Spectrum Disorder (ASD). How SHANK3 insufficiency affects specific neural circuits and this is related to specific ASD symptoms remains elusive. Here we used shRNA to model Shank...

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Détails bibliographiques
Publié dans:Nat Neurosci
Auteurs principaux: Bariselli, Sebastiano, Tzanoulinou, Stamatina, Glangetas, Christelle, Prévost-Solié, Clément, Pucci, Luca, Viguié, Joanna, Bezzi, Paola, O’Connor, Eoin C., Georges, François, Lüscher, Christian, Bellone, Camilla
Format: Artigo
Langue:Inglês
Publié: 2016
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4948673/
https://ncbi.nlm.nih.gov/pubmed/27273769
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nn.4319
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