SHANK3 controls maturation of social reward circuits in the VTA

Haploinsufficiency of SHANK3, encoding the synapse scaffolding protein SHANK3, leads to a highly penetrant form of Autism Spectrum Disorder (ASD). How SHANK3 insufficiency affects specific neural circuits and this is related to specific ASD symptoms remains elusive. Here we used shRNA to model Shank...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Nat Neurosci
Prif Awduron: Bariselli, Sebastiano, Tzanoulinou, Stamatina, Glangetas, Christelle, Prévost-Solié, Clément, Pucci, Luca, Viguié, Joanna, Bezzi, Paola, O’Connor, Eoin C., Georges, François, Lüscher, Christian, Bellone, Camilla
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2016
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4948673/
https://ncbi.nlm.nih.gov/pubmed/27273769
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nn.4319
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