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N-Phenylbenzamides as Potent Inhibitors of the Mitochondrial Permeability Transition Pore

Persistent opening of the mitochondrial permeability transition pore (PTP), an inner membrane channel, leads to mitochondrial dysfunction and renders the PTP a therapeutic target for a host of life-threatening diseases. Herein, we report our effort toward identifying small-molecule inhibitors agains...

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Publicat a:ChemMedChem
Autors principals: Roy, Sudeshna, Šileikytė, Justina, Neuenswander, Benjamin, Hedrick, Michael P., Chung, Thomas D. Y., Aubé, Jeffrey, Schoenen, Frank J., Forte, Michael A., Bernardi, Paolo
Format: Artigo
Idioma:Inglês
Publicat: 2015
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4948641/
https://ncbi.nlm.nih.gov/pubmed/26693836
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cmdc.201500545
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