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Discovery, Synthesis, and Optimization of Diarylisoxazole-3-carboxamides as Potent Inhibitors of the Mitochondrial Permeability Transition Pore
The mitochondrial permeability transition pore (mtPTP) is a Ca(2+)-requiring mega-channel which, under pathological conditions, leads to the deregulated release of Ca(2+) and mitochondrial dysfunction, ultimately resulting in cell death. Although the mtPTP is a potential therapeutic target for many...
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| Publicat a: | ChemMedChem |
|---|---|
| Autors principals: | , , , , , , , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2015
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4674087/ https://ncbi.nlm.nih.gov/pubmed/26286375 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cmdc.201500284 |
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