Discovery, Synthesis, and Optimization of Diarylisoxazole-3-carboxamides as Potent Inhibitors of the Mitochondrial Permeability Transition Pore

The mitochondrial permeability transition pore (mtPTP) is a Ca(2+)-requiring mega-channel which, under pathological conditions, leads to the deregulated release of Ca(2+) and mitochondrial dysfunction, ultimately resulting in cell death. Although the mtPTP is a potential therapeutic target for many...

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Pubblicato in:ChemMedChem
Autori principali: Roy, Sudeshna, Šileikytė, Justina, Schiavone, Marco, Neuenswander, Benjamin, Argenton, Francesco, Aubé, Jeffrey, Hedrick, Michael P., Chung, Thomas D. Y., Forte, Michael A., Bernardi, Paolo, Schoenen, Frank J.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2015
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4674087/
https://ncbi.nlm.nih.gov/pubmed/26286375
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cmdc.201500284
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